Nutramax Laboratories Cobalequin B12 Supplement for Medium t

The Verdict

If your dog has been dragging through walks, losing weight despite a healthy appetite, or dealing with chronic digestive issues, B12 deficiency might be the silent culprit. Nutramax’s Cobalequin is the supplement most veterinarians reach for — and with 240 ratings averaging 4.8 stars, it’s clearly earning its keep in real households.

What You’re Actually Getting

The bottle contains 45 chewable tablets designed specifically for medium to large dogs (roughly 25-75 pounds). Each chewable delivers 1,000 mcg of methylcobalamin — not the cheaper cyanocobalamin found in most grocery store brands. That distinction matters: methylcobalamin is the naturally occurring, bioactive form of B12 that your dog’s body can use immediately without conversion.

The tablets are chicken-liver flavored. That’s not a marketing gimmick — it’s practical. Anyone who’s tried to force a pill down a reluctant dog’s throat knows the value of a chewable that reads as a treat.

Real-World Performance

Dogs with B12 deficiency typically show gastrointestinal symptoms and lethargy. Owners report noticeable changes in both areas, though patience is required. One reviewer noted: “My senior German Shepherd had chronic diarrhea for months. After three weeks on Cobalequin, her stools firmed up and she started acting like a puppy again.”

The absorption factor matters here. Because methylcobalamin bypasses the need for intrinsic factor in the gut (which is often compromised in dogs with GI issues), it works even when the digestive system isn’t functioning optimally. That’s why vets specifically recommend this form over standard B12.

What Owners Consistently Praise

• Palatability: Nearly every review mentions the dog eats these willingly. “My picky Shiba Inu thinks these are treats. She comes running when she hears the bottle.”
• Effectiveness for anemia and GI issues: Multiple owners report improved blood work at follow-up vet visits.
• Trust in the brand: Nutramax is the same company behind Cosequin and Dasuquin — the joint supplements vets have recommended for decades. That reputation carries weight.

Where It Falls Short

Let’s be honest about the tradeoffs. This is not a cheap supplement. Generic B12 tablets cost a fraction of what Cobalequin runs, and if your dog doesn’t have a diagnosed deficiency, you’re paying a premium for a product that may not deliver visible results. Some owners also note their dogs experienced no dramatic changes — typically because the deficiency wasn’t the root cause of their symptoms.

And if your dog has a chicken allergy or sensitivity, the liver flavoring makes this product unusable. You’ll need to look at alternative B12 formulations with different flavor bases.

Who Should Buy This

• Dogs with diagnosed B12 deficiency (especially breeds like German Shepherds and Golden Retrievers prone to gastrointestinal disorders)
• Senior dogs with age-related cognitive decline or diminished appetite
• Dogs recovering from intestinal surgery or chronic pancreatitis
• Owners who’ve tried generic B12 with no results — the methylcobalamin form genuinely absorbs better

FAQ

Q: How long until I see results? Most owners report improvements in energy and digestion within 2-4 weeks of daily dosing. Full restoration of B12 levels typically takes 4-6 weeks. Don’t expect overnight miracles.

Q: Can I give this to a small dog? This specific product is formulated for medium to large breeds. Nutramax makes a separate small dog version with adjusted dosing. Check with your vet for the correct product and dosage.

Q: Is it safe with other medications? B12 is water-soluble, and excess is excreted in urine, making it generally very safe. However, always confirm with your vet if your dog is on metformin, proton pump inhibitors, or other meds that can interfere with B12 absorption.

The Verdict

Buy it if: Your vet has confirmed or suspected a B12 deficiency, your dog has chronic GI issues, or you’ve tried cheaper B12 supplements without results.

Skip it if: Your dog is otherwise healthy and you’re looking for a general multivitamin — this is a targeted therapeutic supplement, not an everyday wellness product. Also skip if your dog has a chicken allergy.

While it’s priced at a premium, the methylcobalamin formulation, palatability, and brand reliability justify the cost for dogs that genuinely need it. The 4.8-star rating holds up under scrutiny — this is a product that delivers what it promises.

Rating: 4.6/5 — Deducting a half-star for the premium pricing and the chicken flavor limitation. Everything else earns top marks.

Where to Buy

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Last updated: 2026-08-06. Ratings and prices current as of review date. Verify on Amazon before purchasing.